Buffalo Bills vs Los Angeles Rams Picks and Predictions for Monday October 12 2026
The Buffalo Bills visit the Los Angeles Rams at SoFi Stadium in Inglewood, California, on Monday, October 12, 2026. Kickoff is scheduled for 8:15 PM ET on Monday Night Football. Both teams enter at 3-1, but they’re coming off very different Week 5 experiences. Buffalo suffered its first loss in a 29-26 home defeat against New England, while Los Angeles went into Philadelphia and earned a 24-20 victory. Buffalo enters as a small road favorite, with the total sitting in the upper 40s. Be sure to check out our free NFL picks for more NFL predictions throughout the season.
Buffalo Faces Its First Real Response Game
Buffalo’s perfect start ended Sunday with a surprising 29-26 home loss to New England. The Bills still scored 26, but they couldn’t get enough defensive stops to avoid the upset.
One loss doesn’t erase the quality Buffalo showed during its 3-0 start. The Bills remain capable of moving the football against almost anyone, and Monday night provides an immediate opportunity to prove the New England result was a temporary setback.
The challenge is that Los Angeles enters with momentum and home field. Buffalo isn’t walking into an easy rebound spot, which makes laying road points considerably less attractive.
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Los Angeles Is Building a Strong Résumé
The Rams improved to 3-1 by going into Philadelphia and earning a 24-20 victory. Winning on the road against a quality opponent gives Los Angeles another reason to be taken seriously entering Monday night.
The Rams have shown an ability to win different types of games. They don’t need everything to turn into a shootout, and that flexibility matters against Buffalo. Los Angeles can remain patient offensively and force the Bills to earn every possession.
Home field also gives the Rams value as an underdog. Buffalo may have the higher overall ceiling, but Los Angeles has done nothing through four games to suggest it should be receiving a meaningful number at SoFi Stadium.
Buffalo Bills vs Los Angeles Rams Picks and Predictions
Pick: Los Angeles Rams ATS
I’m taking the Rams with the points. Buffalo deserves respect after its 3-0 start, but the Bills just surrendered 29 at home to New England and now travel across the country to face another 3-1 team. Los Angeles is coming off an impressive road victory in Philadelphia and gets Buffalo at SoFi Stadium. In a matchup between teams with identical records, I’ll gladly take the home underdog.
Pick: Under
The Under is my total pick. Buffalo’s 29-26 loss naturally points toward the Over, but Los Angeles has shown it can win without turning games into track meets. The Rams just held Philadelphia to 20 points and should prefer a controlled game that limits Buffalo’s possessions. With the total sitting in the upper 40s, there is enough room for a competitive 24-21 or 24-23 finish to stay below the number.
Final Picks: Los Angeles Rams ATS and Under
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